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Human autoantibodies and their genes.

作者信息

Zouali M

机构信息

Institut Pasteur, Immunogénétique Cellulaire, Paris, France.

出版信息

Appl Biochem Biotechnol. 1994 May-Jun;47(2-3):135-41; discussion 141-2. doi: 10.1007/BF02787930.

DOI:10.1007/BF02787930
PMID:7944333
Abstract

We undertook an analysis of the B cell repertoire at both the germline and somatic levels. To assess the content and organization of the IgH-V and IgK-V loci in SLE, endonuclease-generated polymorphisms were used to characterize individual variations within the human V gene segments. The results are compatible with the conclusion that this disease is not caused by major abnormalities in the structure, size, or organization of the IgV loci. We propose that hyperproduction and lupus-associated autoantibodies arises through a two-stage mechanism whereby a general activation of the multireactive preimmune B-cell repertoire precedes oligoclonal expansion of selected B cell clonotypes.

摘要

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本文引用的文献

1
Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus.来自一名狼疮患者的致病性抗DNA自身抗体的克隆型优势和可变基因元件
Scand J Immunol. 1994 Feb;39(2):165-78. doi: 10.1111/j.1365-3083.1994.tb03356.x.
2
Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype.携带狼疮相关致肾炎性抗DNA独特型的人自身抗体所表达的重链可变区基因中的体细胞多样化。
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):514-8. doi: 10.1073/pnas.91.2.514.
3
The 1982 revised criteria for the classification of systemic lupus erythematosus.
1982年系统性红斑狼疮分类的修订标准。
Arthritis Rheum. 1982 Nov;25(11):1271-7. doi: 10.1002/art.1780251101.
4
Organization and evolution of variable region genes of the human immunoglobulin heavy chain.人类免疫球蛋白重链可变区基因的组织与进化
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Origin and diversification of anti-DNA antibodies.抗DNA抗体的起源与多样化
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Toward a layered immune system.迈向分层免疫系统。
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7
Beyond clonal selection and network.超越克隆选择和网络。
Immunol Rev. 1989 Aug;110:63-87. doi: 10.1111/j.1600-065x.1989.tb00027.x.
8
Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.初级抗体形成细胞和次级B细胞由不同的前体细胞亚群产生。
Cell. 1989 Dec 22;59(6):1049-59. doi: 10.1016/0092-8674(89)90761-7.
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Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes.利用爱泼斯坦-巴尔病毒探究人类B细胞库：多反应性抗体和CD5⁺ B淋巴细胞
Annu Rev Immunol. 1989;7:513-35. doi: 10.1146/annurev.iy.07.040189.002501.
10
Clonotypes of anti-DNA antibodies expressing specific idiotypes in immune complexes of patients with active lupus nephritis.
J Immunol. 1990 May 15;144(10):3856-61.