Lévy-Soussan P, Berneman A, Poirier M F, Galinowski A, Loo H, Olié J P, Avrameas S
University of Paris, Paris V, Cochin, Ste-Anne Hospital, France.
J Psychiatry Neurosci. 1996 Mar;21(2):89-95.
The expression of IgG and IgM autoantibodies directed against various autoantigens, either part of the central nervous system or not, was investigated in the sera of inpatients with schizophrenia (n = 10). An enzyme immunoassay was used to measure the levels of these autoantibodies in whole sera, IgG-depleted sera, and isolated IgG fractions. IgG and IgM antibodies, reacting with all the antigens tested, were present in the sera of patients with schizophrenia as well as in the sera of normal individuals. Among patients suffering from schizophrenia, IgM natural autoantibody reactivities could be higher (myoglobin, serotonin, tubulin), lower (dopamine), or even identical to those of normal individuals, depending on whether whole or fractionated sera were assayed and on the group of patients with schizophrenia (responders and nonresponders) considered. The isolated IgG fractions of patients suffering from schizophrenia had higher anti-DNA and antiserotonin reactivities than those detected in normal individuals.
我们对10例精神分裂症住院患者血清中针对各种自身抗原（无论是否为中枢神经系统的一部分）的IgG和IgM自身抗体表达进行了研究。采用酶免疫测定法测量全血清、去除IgG的血清和分离出的IgG组分中这些自身抗体的水平。与所有测试抗原发生反应的IgG和IgM抗体存在于精神分裂症患者血清以及正常个体血清中。在精神分裂症患者中，IgM天然自身抗体反应性可能更高（肌红蛋白、血清素、微管蛋白）、更低（多巴胺），甚至与正常个体相同，这取决于检测的是全血清还是分离后的血清，以及所考虑的精神分裂症患者组（反应者和无反应者）。精神分裂症患者分离出的IgG组分比正常个体检测到的具有更高的抗DNA和抗血清素反应性。
