Sugiyama Y, Saji S, Miya K, Fukada D, Umemoto T, Kunieda K, Takao H, Kato M, Tsuji K
2nd Dept. of Surgery, Gifu University School of Medicine.
Gan To Kagaku Ryoho. 1995 Sep;22(11):1460-3.
A new modality of locoregional chemotherapy based on biochemical double modulation of 5-fluorouracil (FU) with both leucovorin (LV) and cisplatin (CDDP) against liver metastases of colorectal cancer was devised. The schedule for the locoregional therapy was as follows; bolus infusion of LV (6 mg/body) followed by 30-minute infusion of CDDP (10 mg/body) and 30-minute infusion of 5-FU (250 mg/body). Four colorectal cancer patients with numerous metastases to both lobes of liver were given intraarterial administration of above anticancer drugs every 1-2 weeks after resection of primary lesions. On the one hand, 3 colorectal cancer patients, who developed a few metastases to both lobes of liver, were treated preventively by the same schedule every 2-3 weeks after the resection of metastatic tumors. As for the clinical (radiographic) response, complete response and partial response were observed in 1 and 2 of 4 patients, respectively. The response rate was 75%. No new lesions appeared for over 1 year by the preventive treatment in 2 of 3 patients, whereas new lesions appeared in one patient at 3 months after discontinuation of treatment because of mild toxicity. The toxicity, however, was within acceptable limits. These results indicated that biochemical double modulation of 5-FU with both LV and CDDP is a very promising locoregional chemotherapy against liver metastases of colorectal cancer.
设计了一种基于亚叶酸钙（LV）和顺铂（CDDP）对5-氟尿嘧啶（FU）进行生化双重调节的局部区域化疗新方法，用于治疗结直肠癌肝转移。局部区域治疗方案如下：静脉推注LV（6mg/人），随后30分钟输注CDDP（10mg/人）和30分钟输注5-FU（250mg/人）。4例肝两叶均有大量转移的结直肠癌患者在原发灶切除后每1 - 2周接受上述抗癌药物动脉内给药。另一方面，3例肝两叶出现少量转移的结直肠癌患者在转移瘤切除后每2 - 3周按相同方案进行预防性治疗。至于临床（影像学）反应，4例患者中分别有1例和2例观察到完全缓解和部分缓解。缓解率为75%。3例患者中有2例通过预防性治疗1年多未出现新病灶，而1例患者因轻度毒性在治疗中断3个月时出现新病灶。然而，毒性在可接受范围内。这些结果表明，LV和CDDP对5-FU进行生化双重调节是一种非常有前景的用于治疗结直肠癌肝转移的局部区域化疗方法。
