Ichikawa W, Togo S, Osanai T, Miyanaga T, Sawai S, Yamashita T, Kawachi Y, Nihei Z, Hirayama R, Mishima Y
Dept. of Surgery, Tojun Hospital.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2212-4.
To investigate the effect of intra-arterial injection of mitoxantrone emulsified with ethiodized oil, forty-eight patients with hepatocellular carcinoma were evaluated. After the treatment, ten of the patients underwent hepatectomy. In the thirty-eight unresected cases, there were 15 (39%) partial responses, which continued 1.2 to 11.8 months (mean, 5.8 months). The 1- and 2- year survival rates were 67% and 38%, respectively. The response rate was higher in cases with tumor under 5 cm in diameter. In the remaining 10 resected cases, the necrotic areas in main nodules ranged from 65% to 100% (mean, 85%). This treatment might be applied effectively to patients with small hepatocellular carcinoma.
为研究动脉内注射米托蒽醌与乙碘油乳剂的效果，对48例肝细胞癌患者进行了评估。治疗后，10例患者接受了肝切除术。在38例未切除的病例中，有15例（39%）出现部分缓解，持续时间为1.2至11.8个月（平均5.8个月）。1年和2年生存率分别为67%和38%。直径小于5 cm的肿瘤病例缓解率更高。在其余10例切除的病例中，主结节的坏死面积为65%至100%（平均85%）。这种治疗方法可能对小肝细胞癌患者有效。
