胰岛素样生长因子I治疗A型胰岛素抵抗综合征的长期随访
Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.
作者信息
Ishihama H, Suzuki Y, Muramatsu K, Nagai M, Kokubo M, Shiraya H, Kawakita A, Nishimura Y, Imamura T, Kobayashi M
机构信息
Department of Paediatrics, Toyohashi Municipal Hospital, Aichi, Japan.
出版信息
Arch Dis Child. 1994 Aug;71(2):144-6. doi: 10.1136/adc.71.2.144.
Abstract
Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.
摘要
胰岛素样生长因子I（IGF-I）是治疗因胰岛素受体疾病导致的胰岛素抵抗型糖尿病的一种有效治疗药物，因为它通过IGF-I受体发挥降血糖作用。一名患有典型A型胰岛素抵抗综合征的女孩接受了IGF-I治疗两年，该治疗在改善高血糖方面有效。然而，这种治疗使多囊卵巢中睾酮的过度分泌加剧。因此，IGF-I治疗可用于控制血糖，但由于其可能加重这些患者高雄激素血症的副作用，使用时需谨慎。
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本文引用的文献
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Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor.患有胰岛素受体自身抗体的女性中，胰岛素抵抗与雄激素过多相关。
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Clarification of signaling pathways mediated by insulin and insulin-like growth factor I receptors in fibroblasts from patients with specific defect in insulin receptor.胰岛素受体存在特定缺陷的患者成纤维细胞中胰岛素和胰岛素样生长因子I受体介导的信号通路的阐明
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