• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.胰岛素样生长因子I治疗A型胰岛素抵抗综合征的长期随访
Arch Dis Child. 1994 Aug;71(2):144-6. doi: 10.1136/adc.71.2.144.
2
Acanthosis nigricans, hirsutism, insulin resistance and insulin receptor defect.黑棘皮症、多毛症、胰岛素抵抗和胰岛素受体缺陷。
Clin Endocrinol (Oxf). 1982 Jul 1;17(1):43-9. doi: 10.1111/j.1365-2265.1982.tb02632.x.
3
[Insulin receptors in syndromes involving acanthosis nigricans and severe insulin resistance].[涉及黑棘皮病和严重胰岛素抵抗综合征中的胰岛素受体]
G Ital Dermatol Venereol. 1982 Mar-Apr;117(2):73-82.
4
A syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans associated with polycystic ovary syndrome: clinical and laboratory features.一种与多囊卵巢综合征相关的高雄激素血症、胰岛素抵抗和黑棘皮症综合征：临床和实验室特征
Horm Res. 1990;33 Suppl 2:27-30. doi: 10.1159/000181562.
5
[Rabson-Mendenhall syndrome].[拉布森-门登霍尔综合征]
Nihon Rinsho. 1994 Oct;52(10):2641-2.
6
Impaired growth in Rabson-Mendenhall syndrome: lack of effect of growth hormone and insulin-like growth factor-I.
J Clin Endocrinol Metab. 1994 Sep;79(3):799-805. doi: 10.1210/jcem.79.3.8077364.
7
Demonstration of a primary (? genetic) defect in insulin receptors in fibroblasts from a patient with the syndrome of insulin resistance and acanthosis nigricans type A.一名患有A型胰岛素抵抗和黑棘皮症综合征患者的成纤维细胞中胰岛素受体原发性（可能为遗传性）缺陷的证明。
J Clin Endocrinol Metab. 1980 Jun;50(6):1139-41. doi: 10.1210/jcem-50-6-1139.
8
[A case of insulin receptor abnormality (type A)].[一例胰岛素受体异常（A型）]
Igaku Kenkyu. 1992 Feb;62(1):25-9.
9
Hyperandrogenism, insulin resistance, acanthosis nigricans, and systemic lupus erythematosis associated with insulin receptor antibodies.高雄激素血症、胰岛素抵抗、黑棘皮病以及与胰岛素受体抗体相关的系统性红斑狼疮。
Metabolism. 1988 Jul;37(7):656-9. doi: 10.1016/0026-0495(88)90085-6.
10
Impaired insulin degradation in a patient with insulin resistance and acanthosis nigricans.一名患有胰岛素抵抗和黑棘皮病患者的胰岛素降解受损。
Am J Med. 1982 Jul;73(1):148-54. doi: 10.1016/0002-9343(82)90942-1.

本文引用的文献

1
Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor.患有胰岛素受体自身抗体的女性中，胰岛素抵抗与雄激素过多相关。
Ann Intern Med. 1982 Dec;97(6):851-5. doi: 10.7326/0003-4819-97-6-851.
2
Insulin resistance by uncleaved insulin proreceptor. Emergence of binding site by trypsin.未裂解的胰岛素原受体导致的胰岛素抵抗。胰蛋白酶诱导结合位点的出现。
Diabetes. 1988 May;37(5):653-6. doi: 10.2337/diab.37.5.653.
3
Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site.未加工的胰岛素原受体在裂解位点的点突变导致胰岛素抵抗。
Biochem Biophys Res Commun. 1988 Jun 16;153(2):657-63. doi: 10.1016/s0006-291x(88)81145-8.
4
Somatomedin-C/insulin-like growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells.生长调节素-C/胰岛素样生长因子I作为培养的大鼠卵巢细胞雄激素生物合成的增强剂。
Endocrinology. 1988 Apr;122(4):1603-12. doi: 10.1210/endo-122-4-1603.
5
Clarification of signaling pathways mediated by insulin and insulin-like growth factor I receptors in fibroblasts from patients with specific defect in insulin receptor.胰岛素受体存在特定缺陷的患者成纤维细胞中胰岛素和胰岛素样生长因子I受体介导的信号通路的阐明
Diabetes. 1988 Nov;37(11):1515-23. doi: 10.2337/diab.37.11.1515.
6
Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells.胰岛素样生长因子I和胰岛素可增强大鼠卵巢膜间质细胞中促黄体生成素诱导的雄激素合成。
Endocrinology. 1988 Aug;123(2):733-9. doi: 10.1210/endo-123-2-733.
7
Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance.一名极度胰岛素抵抗患者转化淋巴细胞中未裂解胰岛素原受体的结合特异性和分子内信号转导
Diabetologia. 1989 Jun;32(6):371-7. doi: 10.1007/BF00277261.
8
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.人类糖尿病与胰岛素受体酪氨酸激酶结构域的突变有关。
Science. 1989 Jul 7;245(4913):66-8. doi: 10.1126/science.2544998.
9
Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.人类糖尿病与胰岛素受体酪氨酸激酶结构域的缺失有关。
Science. 1989 Jul 7;245(4913):63-6. doi: 10.1126/science.2544997.
10
Rapid and reliable protocol for direct sequencing of material amplified by the polymerase chain reaction.用于对聚合酶链反应扩增产物进行直接测序的快速可靠方案。
Biotechniques. 1990 Jul;9(1):66-8, 70, 72.

胰岛素样生长因子I治疗A型胰岛素抵抗综合征的长期随访

Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.

作者信息

Ishihama H, Suzuki Y, Muramatsu K, Nagai M, Kokubo M, Shiraya H, Kawakita A, Nishimura Y, Imamura T, Kobayashi M

机构信息

Department of Paediatrics, Toyohashi Municipal Hospital, Aichi, Japan.

出版信息

Arch Dis Child. 1994 Aug;71(2):144-6. doi: 10.1136/adc.71.2.144.

DOI:10.1136/adc.71.2.144
PMID:7944536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1029947/
Abstract

Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.

摘要

胰岛素样生长因子I（IGF-I）是治疗因胰岛素受体疾病导致的胰岛素抵抗型糖尿病的一种有效治疗药物，因为它通过IGF-I受体发挥降血糖作用。一名患有典型A型胰岛素抵抗综合征的女孩接受了IGF-I治疗两年，该治疗在改善高血糖方面有效。然而，这种治疗使多囊卵巢中睾酮的过度分泌加剧。因此，IGF-I治疗可用于控制血糖，但由于其可能加重这些患者高雄激素血症的副作用，使用时需谨慎。