Genton B, Hii J, al-Yaman F, Paru R, Beck H P, Ginny M, Dagoro H, Lewis D, Alpers M P
Papua New Guinea Institute of Medical Research, Madang.
Ann Trop Med Parasitol. 1994 Jun;88(3):263-70. doi: 10.1080/00034983.1994.11812866.
The effect of bednet use was investigated, without undertaking a specific intervention, in four cross-sectional community-based surveys in 10 villages of a highly endemic area of Papua New Guinea. Over half (55%) of the villagers interviewed reported that they had used a bednet on the previous night. In general and after adjustment for age, village and housing characteristics, bednet users, particularly children, had lower parasite prevalences and spleen rates and less enlarged spleens than non-users. However, users were similar to non-users in terms of fever reported for the previous week, axillary temperature, parasite density and haemoglobin level. The prevalence of antibody to the ring erythrocyte surface antigen and the major merozoite surface antigen 2 was lower in users than non-users. The association with malariometric indices and immune responses remained significant when bednet users were compared with non-users in houses without bednets. Thus, untreated bednets do not reduce malaria transmission sufficiently to decrease morbidity. They might paradoxically increase the risk of clinical malaria by lowering the development of humoral immunity.
在巴布亚新几内亚一个高度流行疟疾地区的10个村庄开展的四项基于社区的横断面调查中，在未进行特定干预的情况下，对使用蚊帐的效果进行了调查。超过半数（55%）接受访谈的村民报告称，他们前一晚使用了蚊帐。总体而言，在对年龄、村庄和住房特征进行调整后，使用蚊帐者，尤其是儿童，与未使用者相比，寄生虫感染率和脾肿大率更低，脾脏肿大程度也更小。然而，在报告的前一周发热情况、腋窝温度、寄生虫密度和血红蛋白水平方面，使用者与未使用者相似。使用蚊帐者对环状红细胞表面抗原和主要裂殖子表面抗原2的抗体流行率低于未使用者。当将使用蚊帐者与未使用蚊帐房屋中的未使用者进行比较时，与疟疾测量指标和免疫反应的关联仍然显著。因此，未处理的蚊帐不能充分减少疟疾传播以降低发病率。它们可能反而会通过降低体液免疫的发展而增加临床疟疾的风险。
