Teeuw K B, Vandenbroucke-Grauls C M, Verhoef J
Eijkman-Winkler Laboratory for Experimental Microbiology, University of Utrecht, The Netherlands.
Arch Intern Med. 1994 Oct 24;154(20):2339-45.
During a survey of building-related symptoms among 1355 employees working in 19 governmental office buildings in the Netherlands, we measured physical and chemical factors, airborne microorganisms, and endotoxin. Mechanically ventilated buildings were grouped as "healthy" or "sick" based on symptom prevalence (mean symptom prevalence < 15% or > or = 15%). We compared physical, chemical, and microbiological characteristics between mechanically ventilated and naturally ventilated buildings.
Gram-negative rods were found in higher numbers in the "sick" buildings. The concentration of airborne endotoxin was six to seven times higher in the "sick" buildings than in the "healthy" buildings (254 vs 46 ng/m3); it was 35 ng/m3 in naturally ventilated buildings. No differences in physical characteristics of the buildings were found. Volatile organic compounds and carbon dioxide were present at higher concentrations in naturally ventilated buildings.
Airborne microbial contamination, in particular with gram-negative rods and perhaps with endotoxin, may have a role in the causation of sick building syndrome.
在对荷兰19栋政府办公楼中1355名员工的建筑相关症状进行调查期间，我们测量了物理和化学因素、空气传播微生物及内毒素。根据症状患病率（平均症状患病率<15%或≥15%），将机械通风建筑分为“健康”或“病态”两类。我们比较了机械通风建筑和自然通风建筑之间的物理、化学和微生物特征。
在“病态”建筑中发现革兰氏阴性杆菌的数量更多。“病态”建筑中空气传播内毒素的浓度比“健康”建筑高6至7倍（254对46 ng/m³）；自然通风建筑中的浓度为35 ng/m³。未发现建筑物理特征存在差异。自然通风建筑中挥发性有机化合物和二氧化碳的浓度更高。
空气传播的微生物污染，特别是革兰氏阴性杆菌以及可能还有内毒素的污染，可能在病态建筑综合征的病因中起作用。
