Bowman S J, Sivakumaran M, Snowden N, Bhavnani M, Hall M A, Panayi G S, Lanchbury J S
UMDS, London, UK.
Arthritis Rheum. 1994 Sep;37(9):1326-30. doi: 10.1002/art.1780370909.
To assess whether the HLA-DR4 association found in rheumatoid arthritis (RA) is also seen in the large granular lymphocyte (LGL) syndrome.
HLA-DR genotyping was performed using restriction fragment length polymorphism and polymerase chain reaction analysis.
LGL syndrome patients with RA showed the same HLA-DR4 association seen in RA/Felty's syndrome (FS), while LGL syndrome patients without arthritis did not.
It is proposed that FS and the LGL syndrome represent different variants of a broader syndrome comprising RA, neutropenia, LGL expansions, HLA-DR4 positivity, and splenomegaly.
评估类风湿关节炎（RA）中发现的HLA - DR4关联是否也存在于大颗粒淋巴细胞（LGL）综合征中。
采用限制性片段长度多态性和聚合酶链反应分析进行HLA - DR基因分型。
患有RA的LGL综合征患者表现出与RA/费尔蒂综合征（FS）相同的HLA - DR4关联，而无关节炎的LGL综合征患者则未表现出这种关联。
有人提出，FS和LGL综合征代表了一种更广泛综合征的不同变体，该综合征包括RA、中性粒细胞减少、LGL增多、HLA - DR4阳性和脾肿大。
