Banerjee A K, Bandyopadhyay S, Gayen A K, Sengupta T, Das A K, Chatterjee G K, Chaudhuri S K
Organon Research Centre, Calcutta, India.
Arzneimittelforschung. 1994 Jul;44(7):863-6.
Isoxazole derivatives have been shown to possess antiparasitic activity. In the present study, 3-substituted 5-methylthio-isoxazoles were synthesized and tested for anthelmintic activity, along with some other isoxazoles which have been reported but not tested earlier. Nine compounds (2a, 2b, 2e, 2g, 2u, 3a, 3b, 3e and 3f) showed activity against both A. ceylanicum and N. dubius in vitro. Twelve compounds (2a, 2b, 2d, 2e, 2f, 2h, 2l, 2n, 2o, 2u, 3d and 3e) showed activity against N. dubius in vivo, a parasite of veterinary importance.
异恶唑衍生物已被证明具有抗寄生虫活性。在本研究中，合成了3-取代的5-甲硫基异恶唑并测试其驱虫活性，同时还测试了一些其他已报道但之前未测试过的异恶唑。九种化合物（2a、2b、2e、2g、2u、3a、3b、3e和3f）在体外对锡兰钩虫和杜氏小杆线虫均有活性。十二种化合物（2a、2b、2d、2e、2f、2h、2l、2n、2o、2u、3d和3e）在体内对杜氏小杆线虫有活性，杜氏小杆线虫是一种具有兽医重要性的寄生虫。
