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新型δ2-1,2,4-恶二唑啉衍生物的合成及其体外抗HIV活性

Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.

作者信息

Chimirri A, Grasso S, Monforte A M, Monforte P, Zappalà M, Carotti A

机构信息

Dipartimento Farmaco-Chimico, Università di Messina, Italy.

出版信息

Farmaco. 1994 Jul-Aug;49(7-8):509-11.

PMID:7945718
Abstract

The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is also reported.

摘要

描述了4-金刚烷基-5-芳基-3-苯基-Δ2-1,2,4-恶二唑啉的合成，该合成涉及1-[(亚芳基)氨基]金刚烷与苯甲腈氧化物之间的1,3-偶极环加成反应。还报道了所获得化合物对人类免疫缺陷病毒（HIV）的体外抗病毒活性评估。

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