Tomlinson B, Woo J, Critchley J A, Or K K, Chan T Y, Sanderson J E
Department of Clinical Pharmacology, Chinese University of Hong Kong, Shatin, New Territories.
Am J Hypertens. 1994 Jul;7(7 Pt 2):35S-39S. doi: 10.1093/ajh/7.7.35s.
The benefits of treating isolated systolic hypertension (ISH) have been established, but the most appropriate choice of drug is still uncertain. For this reason, a sustained-release formulation of isradipine was compared with spirapril in a double-blind randomized study in elderly Chinese patients with ISH. The dosage was titrated if necessary after 4 weeks of treatment. The reduction in systolic/diastolic blood pressure after 8 weeks was similar for both treatments--20/10 mm Hg with isradipine versus 24/6 mm Hg with spirapril--measured in the supine position. There were no orthostatic symptoms and both treatments were well tolerated.
治疗单纯收缩期高血压（ISH）的益处已得到证实，但最适宜的药物选择仍不明确。因此，在一项针对中国老年ISH患者的双盲随机研究中，对伊拉地平缓释制剂与螺普利进行了比较。治疗4周后如有必要可调整剂量。8周后，两种治疗方法仰卧位收缩压/舒张压的降低幅度相似——伊拉地平降低20/10 mmHg，螺普利降低24/6 mmHg。未出现直立性症状，两种治疗耐受性均良好。
