Pries F, van der Ploeg J R, Dolfing J, Janssen D B
Department of Biochemistry, University of Groningen, The Netherlands.
FEMS Microbiol Rev. 1994 Oct;15(2-3):279-95. doi: 10.1111/j.1574-6976.1994.tb00140.x.
A limited number of halogenated aliphatic compounds can serve as a growth substrate for aerobic microorganisms. Such cultures have (specifically) developed a variety of enzyme systems to degrade these compounds. Dehalogenations are of critical importance. Various heavily chlorinated compounds are not easily biodegraded, although there are no obvious biochemical or thermodynamic reasons why microorganisms should not be able to grow with any halogenated compound. The very diversity of catabolic enzymes present in cultures that degrade halogenated aliphatics and the occurrence of molecular mechanisms for genetic adaptation serve as good starting points for the evolution of catabolic pathways for compounds that are currently still resistant to biodegradation.
少数卤代脂肪族化合物可用作好氧微生物的生长底物。这类培养物（特别地）已形成了多种酶系统来降解这些化合物。脱卤作用至关重要。各种高度氯化的化合物不易被生物降解，尽管从生化或热力学角度来看，微生物没有明显理由不能利用任何卤代化合物生长。在降解卤代脂肪族化合物的培养物中存在的分解代谢酶的多样性以及遗传适应的分子机制的出现，是目前仍抗生物降解的化合物分解代谢途径进化的良好起点。
