四种静脉诱导剂对体外T淋巴细胞对PHA增殖反应的影响。
Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro.
作者信息
Devlin E G, Clarke R S, Mirakhur R K, McNeill T A
机构信息
University Department of Anaesthetics, Queen's University, Belfast, N. Ireland.
出版信息
Br J Anaesth. 1994 Sep;73(3):315-7. doi: 10.1093/bja/73.3.315.
PMID:7946855
Abstract
Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.
摘要
麻醉剂被认为会对人体免疫力产生不良影响。我们研究了四种静脉诱导剂，硫喷妥钠、美索比妥、依托咪酯和丙泊酚，对体外植物血凝素刺激的T淋巴细胞增殖的影响。我们发现，在与诱导剂量后获得的血浆浓度相似的情况下，除丙泊酚外，所有药物均会导致T淋巴细胞功能抑制。
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