Calzavara M, Fusetti F, Magri E, Pase U
Minerva Stomatol. 1976 Apr-Jun;25(2):55-66.
Tibezonium iodide is a new drug having antibacterial activity for the therapy and the prevention of mouth infections. Before testing its therapeutic efficacy, its effect on the bacterial flora of the human saliva was verified as follows. Salivary samples, collected before and after the administration (double-blind, cross-over) to volunteers, were counted for bacteria. The drug reduced the bacterial count in the saliva with statistical significance in both the pharmaceutical forms. Subsequently the drug was tested in different dental or oral conditions. To 90 patients suffering from marginal paradentitis or other diseases with this type of complications tablets were administered. The results obtained in this group were satisfactory or almost satisfactory in 73.5% of the cases examined. The patients treated with bubble-gums were 70. All of them were suffering from the same kind of disease of the first group; a few of them had alveolitis following tooth extraction. The results in these subjects were satisfactory or almost satisfactory in 77% of the cases examined. Tibezonium proved to be particularly effective in marginal paradentitis and in piorrhoic paradontosis. Bubble-gums should not be used in subjects with dental mobile prosthesis.
碘替唑铵是一种具有抗菌活性的新药，用于治疗和预防口腔感染。在测试其治疗效果之前，先对其对人类唾液中细菌群落的影响进行了如下验证。在志愿者给药前后（双盲、交叉）采集唾液样本，对细菌进行计数。两种剂型的药物均能使唾液中的细菌数量显著减少。随后，该药物在不同的牙齿或口腔疾病中进行了测试。给90名患有边缘性牙周炎或其他伴有此类并发症疾病的患者服用片剂。在该组检查的病例中，73.5%的结果令人满意或几乎令人满意。使用口香糖治疗的患者有70名。他们都患有与第一组相同类型的疾病；其中一些人拔牙后出现牙槽炎。在这些受试者中，77%的检查病例结果令人满意或几乎令人满意。碘替唑铵在边缘性牙周炎和脓性牙周病中被证明特别有效。有可摘假牙的患者不应使用口香糖。
