艾滋病患者单次静脉注射氟康唑后的药代动力学。
The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients.
作者信息
Yeates R A, Ruhnke M, Pfaff G, Hartmann A, Trautmann M, Sarnow E
机构信息
Pfizer-Mack Ltd, Illertissen, Germany.
出版信息
Br J Clin Pharmacol. 1994 Jul;38(1):77-9. doi: 10.1111/j.1365-2125.1994.tb04325.x.
Abstract
The pharmacokinetics of fluconazole after a single 100 mg i.v. dose were studied in 10 healthy subjects (5 M; 5 F) and 10 HIV-positive patients (8 M; 2 F). The mean value of plasma clearance was 25% lower in the patient groups (17 +/- 6 (s.d.) vs 23 +/- 4 ml min-1; 95% CI of difference -11 to -0.7; P < 0.05). This difference may have been related to slightly reduced kidney function in the patient group (mean creatinine clearance -18%) but is unlikely to be clinically significant. Therefore, no adjustment of the dose of intravenously administered fluconazole appears to be necessary in AIDS patients without clinical signs of enteropathy.
摘要
在10名健康受试者（5名男性；5名女性）和10名HIV阳性患者（8名男性；2名女性）中研究了单次静脉注射100毫克氟康唑后的药代动力学。患者组的血浆清除率平均值低25%（17±6（标准差）对23±4毫升/分钟；差异的95%置信区间为-11至-0.7；P<0.05）。这种差异可能与患者组肾功能略有降低（平均肌酐清除率-18%）有关，但不太可能具有临床意义。因此，在没有肠道疾病临床体征的艾滋病患者中，似乎无需调整静脉注射氟康唑的剂量。
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本文引用的文献
1
Fluconazole penetration into cerebrospinal fluid in humans.
J Clin Pharmacol. 1988 Apr;28(4):363-6. doi: 10.1002/j.1552-4604.1988.tb03159.x.
2
Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients.
J Med Vet Mycol. 1988 Feb;26(1):67-71. doi: 10.1080/02681218880000081.
3
Drug interactions with fluconazole.氟康唑的药物相互作用。
Rev Infect Dis. 1990 Mar-Apr;12 Suppl 3:S327-33. doi: 10.1093/clinids/12.supplement_3.s327.
4
Pharmacokinetics and tissue penetration of fluconazole in humans.氟康唑在人体内的药代动力学和组织穿透性。
Rev Infect Dis. 1990 Mar-Apr;12 Suppl 3:S318-26. doi: 10.1093/clinids/12.supplement_3.s318.
5
Azoles and AIDS.唑类药物与艾滋病
J Infect Dis. 1990 Sep;162(3):727-30. doi: 10.1093/infdis/162.3.727.
6
Renal failure in patients with AIDS-related complex.艾滋病相关综合征患者的肾衰竭
Urology. 1991 Jun;37(6):523-7. doi: 10.1016/0090-4295(91)80316-y.
7
Fluconazole. Review and situation among antifungal drugs in the treatment of opportunistic mycoses of human immuno-deficiency virus infections.氟康唑。抗真菌药物治疗人类免疫缺陷病毒感染机会性真菌病的综述及现状。
Pharm Weekbl Sci. 1991 Apr 26;13(2):45-57. doi: 10.1007/BF01974981.
8
Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group.两性霉素B与氟康唑治疗急性艾滋病相关隐球菌性脑膜炎的比较。美国国立过敏与传染病研究所真菌病研究组及艾滋病临床试验组。
N Engl J Med. 1992 Jan 9;326(2):83-9. doi: 10.1056/NEJM199201093260202.
9
A controlled trial of fluconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome. The NIAID AIDS Clinical Trials Group and Mycoses Study Group.一项关于氟康唑或两性霉素B预防获得性免疫缺陷综合征患者隐球菌性脑膜炎复发的对照试验。美国国立过敏和传染病研究所艾滋病临床试验组及真菌病研究组。
N Engl J Med. 1992 Mar 19;326(12):793-8. doi: 10.1056/NEJM199203193261203.
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