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酵母细胞周期突变体cdc21是一种温度敏感型胸苷酸营养缺陷型菌株。

Yeast cell-cycle mutant cdc21 is a temperature-sensitive thymidylate auxotroph.

作者信息

Game J C

出版信息

Mol Gen Genet. 1976 Aug 2;146(3):313-5. doi: 10.1007/BF00701257.

DOI:10.1007/BF00701257
PMID:794696
Abstract

Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5'-monophosphate (dTMP). Yeast strains carrying cdc21 can grow at 37 degrees in the presence of dTMP provided that they are premeable to this compound. The gene is shown to be linked to ade2 on Chr. XV, and a case of intragenic complementation between cdc21 and another tmp1 allele is reported.

摘要

对哈特韦尔分离出的酵母细胞周期突变体cdc21进行的基因测试表明，酵母中的CDC21基因与TMP1基因相同，其突变等位基因赋予对胸苷-5'-单磷酸（dTMP）的营养缺陷型需求。携带cdc21的酵母菌株在dTMP存在的情况下可以在37摄氏度生长，前提是它们对这种化合物是可渗透的。该基因被证明与第十五号染色体上的ade2相连，并且报道了cdc21与另一个tmp1等位基因之间的基因内互补情况。

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Yeast cell-cycle mutant cdc21 is a temperature-sensitive thymidylate auxotroph.酵母细胞周期突变体cdc21是一种温度敏感型胸苷酸营养缺陷型菌株。
Mol Gen Genet. 1976 Aug 2;146(3):313-5. doi: 10.1007/BF00701257.
2
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J Bacteriol. 1977 Oct;132(1):44-50. doi: 10.1128/jb.132.1.44-50.1977.
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A simple method for the isolation and characterization of thymidylate uptaking mutants in Saccharomyces cerevisiae.一种用于分离和鉴定酿酒酵母胸苷酸摄取突变体的简单方法。
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Isolation of the thymidylate synthetase gene (TMP1) by complementation in Saccharomyces cerevisiae.通过在酿酒酵母中进行互补作用分离胸苷酸合成酶基因（TMP1）。
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Isolation and properties of yeast mutants with highly efficient thymidylate utilization.高效利用胸苷酸的酵母突变体的分离与特性
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Induction of mitotic recombination in yeast by starvation for thymine nucleotides.胸腺嘧啶核苷酸饥饿诱导酵母中的有丝分裂重组。
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Nucleic acid metabolism in yeast II. Metabolism of thymidylate during thymidylate excess death.酵母中的核酸代谢II.胸苷酸过量致死期间胸苷酸的代谢
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Enhanced canavanine uptake is associated with nucleotide permeability in a thymidylate auxotroph of Saccharomyces cerevisiae.在酿酒酵母的胸苷酸营养缺陷型中，刀豆氨酸摄取增强与核苷酸通透性相关。
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Nucleic acid metabolism in yeast, V. Excretion of thymidylate.酵母中的核酸代谢，V. 胸苷酸的排泄
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本文引用的文献

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Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.酵母细胞分裂周期的遗传控制：V. cdc 突变体的遗传分析。
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The cdc22 gene of Schizosaccharomyces pombe encodes a cell cycle-regulated transcript.裂殖酵母 cdc22 基因编码一个细胞周期调控的转录本。
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Nuclear morphology of yeast under thymidylate starvation.胸苷酸饥饿条件下酵母的细胞核形态
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Genetic map of Saccharomyces cerevisiae.酿酒酵母的遗传图谱。
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The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae.酿酒酵母中新的DNA合成突变体的分离。
Mol Gen Genet. 1982;186(3):439-44. doi: 10.1007/BF00729466.
10
Exogenous dTMP utilization by a novel tup mutant of Saccharomyces cerevisiae.酿酒酵母新型tup突变体对外源胸苷酸的利用
J Bacteriol. 1982 Oct;152(1):111-9. doi: 10.1128/jb.152.1.111-119.1982.
酵母细胞分裂周期的遗传控制。I. 突变体的检测。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):352-9. doi: 10.1073/pnas.66.2.352.
4
Kinetics and genetic control of the incorporation of thymidine monophosphate in yeast DNA.酵母DNA中一磷酸胸苷掺入的动力学及遗传控制
Mol Gen Genet. 1972;117(1):39-44. doi: 10.1007/BF00268835.
5
"Thymineless death" in a strain of Saccharomyces cerevisiae auxotrophic for deoxythymidine-5'-monophosphate.在一株对脱氧胸苷 -5'- 单磷酸营养缺陷的酿酒酵母中发生的“无胸腺嘧啶死亡”
Mol Gen Genet. 1974;131(4):351-8. doi: 10.1007/BF00264865.
6
Economizing DNA-specific labelling by deoxythymidine-5'-monophosphate in Saccharomyces cerevisiae.通过脱氧胸苷 -5'-单磷酸在酿酒酵母中实现DNA特异性标记的节约。
Mol Gen Genet. 1974;132(4):335-45. doi: 10.1007/BF00268573.
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Saccharomyces cerevisiae cell cycle.酿酒酵母细胞周期。
Bacteriol Rev. 1974 Jun;38(2):164-98. doi: 10.1128/br.38.2.164-198.1974.
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Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae.酿酒酵母中脱氧核糖核酸合成所需的另外三个基因。
J Bacteriol. 1973 Sep;115(3):966-74. doi: 10.1128/jb.115.3.966-974.1973.
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Mutants for the specific labelling of DNA in Saccharomyces cerevisiae.用于酿酒酵母DNA特异性标记的突变体。
Biochim Biophys Acta. 1973 Apr 11;299(4):681-5. doi: 10.1016/0005-2787(73)90243-8.
10
Isolation and characterization of mutants of Saccharomyces cerevisiae auxotrophic and conditionally auxotrophic for 5'-dTMP.酿酒酵母对5'-脱氧胸苷酸营养缺陷型和条件营养缺陷型突变体的分离与鉴定。
Z Naturforsch C Biosci. 1974 Nov-Dec;29(11-12):733-8. doi: 10.1515/znc-1974-11-1214.