Katoh A, Watzlaf V J, D'Amico F
Department of Laboratory Medicine, Mercy Hospital, Pittsburgh, Pennsylvania 15219-5166.
Br J Cancer. 1994 Nov;70(5):928-33. doi: 10.1038/bjc.1994.422.
A historical prospective study was conducted at the Mercy Hospital of Pittsburgh, Pennsylvania (USA), to study the role of post-menopausal obesity in the recurrence and survival of breast cancer. Records from 301 post-menopausal women diagnosed with breast cancer from 1977 to 1985 were followed for at least 5 years from data supplied by the Tumor Registry and medical records. Data collected included age, height, weight, race, hormone receptor status, stage and size of tumour, number of positive nodes, site of distant metastasis, first course of treatment, and 5 year recurrence and survival. Forty-five per cent of patients were obese (n = 136), while 55% were non-obese (n = 165). Obesity was defined by the Quetelet index (patients with values > 27 were considered obese). The recurrence rates for the obese and non-obese groups were 40% and 39% respectively, and were not significantly different. Univariate and multivariate analyses showed that there was no significant association between obesity in post-menopausal women and likelihood of recurrence of or death from breast cancer.
在美国宾夕法尼亚州匹兹堡市的梅西医院开展了一项历史性前瞻性研究，以探究绝经后肥胖在乳腺癌复发和生存中的作用。根据肿瘤登记处提供的数据和病历，对1977年至1985年期间诊断为乳腺癌的301名绝经后女性的记录进行了至少5年的随访。收集的数据包括年龄、身高、体重、种族、激素受体状态、肿瘤分期和大小、阳性淋巴结数量、远处转移部位、首次治疗过程以及5年复发率和生存率。45%的患者肥胖（n = 136），而55%的患者不肥胖（n = 165）。肥胖通过奎特利指数定义（指数值> 27的患者被视为肥胖）。肥胖组和非肥胖组的复发率分别为40%和39%，差异无统计学意义。单因素和多因素分析表明，绝经后女性肥胖与乳腺癌复发或死亡可能性之间无显著关联。
