Stalder J F, Fleury M, Sourisse M, Rostin M, Pheline F, Litoux P
Department of Dermatology, Hôtel-Dieu, CHU, Nantes, France.
Br J Dermatol. 1994 Oct;131(4):536-40. doi: 10.1111/j.1365-2133.1994.tb08556.x.
A double-blind, randomized trial was conducted to determine the influence of topical steroid therapy on atopic skin flora. The bacteriological and clinical effects of desonide (Locapred), compared with those of its excipient, were studied in 40 children. Clinical scoring and bacteriological sampling were performed before the start of the trial and after 7 days of once-daily topical treatment. Before treatment, no differences in clinical score or Staphylococcus aureus colonization were noted between the two groups. After treatment, the clinical score improved (P < 0.001) in the desonide group, and S. aureus density decreased dramatically (P < 0.001). In the excipient group, no significant differences in clinical score or S. aureus density were noted. A comparison of the two groups demonstrated statistically significant differences with regard to clinical score (P < 0.001) and S. aureus density (P < 0.05). These results show the efficacy of topical corticosteroid treatment alone on S. aureus colonization in atopic skin, and confirm the critical role of inflammation in bacterial colonization.
进行了一项双盲随机试验，以确定局部类固醇疗法对特应性皮肤菌群的影响。在40名儿童中研究了地奈德（Locapred）与其辅料相比的细菌学和临床效果。在试验开始前以及每日一次局部治疗7天后进行临床评分和细菌学采样。治疗前，两组在临床评分或金黄色葡萄球菌定植方面未发现差异。治疗后，地奈德组的临床评分有所改善（P < 0.001），金黄色葡萄球菌密度显著降低（P < 0.001）。在辅料组中，临床评分或金黄色葡萄球菌密度未发现显著差异。两组比较显示，在临床评分（P < 0.001）和金黄色葡萄球菌密度（P < 0.05）方面存在统计学上的显著差异。这些结果表明局部皮质类固醇治疗对特应性皮肤中金黄色葡萄球菌定植的有效性，并证实了炎症在细菌定植中的关键作用。
