Nagata T, Kage S, Kimura K, Kudo K, Imamura T
Department of Forensic Medicine, Faculty of Medicine, Kyushu University 60, Fukuoka, Japan.
Int J Legal Med. 1994;106(6):288-90. doi: 10.1007/BF01224772.
We carried out animal experiments to toxicologically verify polysulphide poisoning by analyzing tissue samples. A bathing agent containing calcium polysulphides was administered orally to rats, and then polysulphides and sulphide, the decomposed product of polysulphides, were analyzed by GC and GC/MS. The concentrations of polysulphides (mumol/ml or g) were found to be highest in blood (0.196), followed by the liver (0.051), the lungs (0.018) and kidneys (0.013), but were below the detection limit (0.005 mumol/g) in the other tissues tested. Sulphide was detected in all the tissue samples and was found to be highest in the blood (0.518 mumol/ml), this being 40 times higher than that required for fatal poisoning in the case of hydrogen sulphide. Polysulphide poisoning was considered to be confirmatively diagnosed by detecting and measuring polysuphides and supplementarily sulphide in body tissues, most pertinently in the blood. Two practical cases of suspected poisoning by polysulphides are briefly described.
我们通过分析组织样本进行了动物实验，以毒理学方式验证多硫化物中毒情况。给大鼠口服一种含多硫化钙的沐浴剂，然后通过气相色谱（GC）和气相色谱-质谱联用仪（GC/MS）分析多硫化物及其分解产物硫化物。结果发现，多硫化物的浓度（微摩尔/毫升或克）在血液中最高（0.196），其次是肝脏（0.051）、肺（0.018）和肾脏（0.013），但在其他测试组织中低于检测限（0.005微摩尔/克）。在所有组织样本中均检测到了硫化物，且在血液中含量最高（0.518微摩尔/毫升），这比硫化氢致死中毒所需浓度高40倍。通过检测和测量身体组织（最关键的是血液）中的多硫化物以及辅助检测硫化物，可确诊多硫化物中毒。简要描述了两例疑似多硫化物中毒的实际病例。
