Macleod A, Kitchener H C, Parkin D E, Sarkar T, Miller I D, Mann E, Gordon N, Campbell M
Department of Gynaecology, Aberdeen Medical School, UK.
Br J Obstet Gynaecol. 1994 Sep;101(9):797-803. doi: 10.1111/j.1471-0528.1994.tb11949.x.
To study survival in women treated for cervical carcinoma in Grampian region, to identify clinical and pathological prognostic factors, and to correlate survival with cytology history.
A retrospective study of all cases of cervical carcinoma using a prospectively gathered database. Data validated by 1 in 10 randomised retrospective case note sampling.
Aberdeen Royal Infirmary.
Three hundred and sixty-three women resident within Grampian diagnosed as having cervical carcinoma between 1980 and 1991, with five-year survival data on the 206 diagnosed by the end of 1986.
Five-year survival rates.
The mean annual incidence of cervical carcinoma in our population was 11.2 per 100,000 women, with an overall five-year survival of 67% in those under 40 years of age and 60% in those aged 40 years and over. On univariate analysis, survival was significantly adversely affected by tumour stage, grade and absence of previous smears. On multivariate analysis, the effect of previous smear history was lost, but stage and grade remained strong independent risk factors for survival. There was no significant difference in five-year survival by age or tumour type.
The prognosis of cervical carcinoma in Grampian region was independently affected only by stage of disease and tumour grading and cervical smear history.
研究格兰扁地区接受宫颈癌治疗的女性的生存率，确定临床和病理预后因素，并将生存率与细胞学检查史相关联。
使用前瞻性收集的数据库对所有宫颈癌病例进行回顾性研究。通过每10例随机抽取回顾性病例记录进行数据验证。
阿伯丁皇家医院。
1980年至1991年间居住在格兰扁地区、被诊断患有宫颈癌的363名女性，其中206名在1986年底前被诊断出，有五年生存率数据。
五年生存率。
我们研究人群中宫颈癌的年平均发病率为每10万名女性11.2例，40岁以下女性的总体五年生存率为67%，40岁及以上女性为60%。单因素分析显示，肿瘤分期、分级以及既往未进行涂片检查对生存率有显著不利影响。多因素分析显示，既往涂片检查史的影响消失，但分期和分级仍然是生存率的强有力独立危险因素。按年龄或肿瘤类型划分的五年生存率无显著差异。
格兰扁地区宫颈癌的预后仅独立受疾病分期、肿瘤分级和宫颈涂片检查史的影响。
