Matsumura S, Ishida T, Washizu T, Tomoda I
Department of Clinical Pathology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
J Vet Med Sci. 1994 Jun;56(3):523-8. doi: 10.1292/jvms.56.523.
Lymph nodes from cats with natural feline immunodeficiency virus (FIV) infection were examined histopathologically for characterization of lesions in the symptomatic and terminal stages. The localization of viral antigen was also studied in the nodes by immunohistochemistry using a monoclonal antibody to FIV p24. In a node of persistent generalized lymphadenopathy stage, follicular hyperplasia was prominent and the viral antigen was demonstrated predominantly in the follicular lymphocytes and tingible body macrophages. In cats died at AIDS related complex stage, the lymph nodes showed either mixed follicular hyperplasia and involution, involution, or mixed involution and depletion. The lymph nodes in those died at AIDS stage showed considerable destruction of the nodal architecture with involution and depletion of lymphoid follicles. In this terminal stage, the viral antigen was seen prominently in histiocytes/macrophages of the sinus. These findings observed in the dead cats were similar to the lymph node changes seen in human AIDS associated with HIV infection. It was suggested that sequential histologic changes from follicular hyperplasia to depletion via involution took place in the FIV infected lymph node with persistence of FIV antigen.
对自然感染猫免疫缺陷病毒（FIV）的猫的淋巴结进行组织病理学检查，以确定症状期和终末期病变的特征。还使用针对FIV p24的单克隆抗体，通过免疫组织化学研究了病毒抗原在淋巴结中的定位。在持续性全身性淋巴结病阶段的一个淋巴结中，滤泡增生明显，病毒抗原主要在滤泡淋巴细胞和含铁血黄素巨噬细胞中显示。在死于艾滋病相关综合征阶段的猫中，淋巴结表现为滤泡增生与退化混合、退化或退化与耗竭混合。死于艾滋病阶段的猫的淋巴结显示出淋巴结结构的相当大破坏，伴有淋巴滤泡的退化和耗竭。在这个终末期，病毒抗原在窦的组织细胞/巨噬细胞中显著可见。在死亡猫中观察到的这些发现与人类艾滋病患者中与HIV感染相关的淋巴结变化相似。有人提出，在FIV感染的淋巴结中，随着FIV抗原的持续存在，会发生从滤泡增生到通过退化耗竭的连续组织学变化。
