Waki Kayoko, Freed Eric O
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.
Viruses. 2010 Aug 1;2(8):1603-1620. doi: 10.3390/v2081603.
Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
巨噬细胞被认为在HIV-1感染的发病机制中起重要作用。它们穿越血脑屏障的能力以及对病毒诱导的细胞病变效应的抗性，使其能够作为长期感染的储存库。因此，探索病毒从巨噬细胞传播到其他巨噬细胞或T淋巴细胞等靶细胞的机制，对于我们理解HIV-1发病机制和向艾滋病进展至关重要，对疫苗和新型抗逆转录病毒疗法的开发也至关重要。本综述概述了目前对巨噬细胞中细胞间传播的理解。
