Nishimura R, Kim H Y, Matsunaga S, Hayashi K, Tamura H, Sasaki N, Takeuchi A
Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.
J Vet Med Sci. 1994 Jun;56(3):559-61. doi: 10.1292/jvms.56.559.
Effects of medetomidine (40 micrograms/kg)-midazolam (0.2 mg/kg) on plasma glucose and insulin concentrations were evaluated in laboratory pigs. Intramuscular injection of medetomidine-midazolam induced a gradual hyperglycemic response associated with hypoinsulinemia which was much smaller than that by 80 micrograms/kg of medetomidine alone and was almost within a physiological fluctuation. These mild responses induced by medetomidine-midazolam were antagonized by use of an alpha 2-adrenoreceptor antagonist atipamezole (160 micrograms/kg), therefore those changes were thought to be mainly attributed to the effect of medetomidine on alpha 2-adrenoreceptors. A combination of medetomidine at a low dose and midazolam reduces undesirable effects, while providing more profound sedation than medetomidine alone in laboratory pigs.
在实验猪中评估了美托咪定（40微克/千克）-咪达唑仑（0.2毫克/千克）对血浆葡萄糖和胰岛素浓度的影响。肌肉注射美托咪定-咪达唑仑可引起与低胰岛素血症相关的逐渐升高的血糖反应，该反应比单独使用80微克/千克美托咪定引起的反应小得多，且几乎在生理波动范围内。美托咪定-咪达唑仑引起的这些轻微反应可被α2-肾上腺素能受体拮抗剂阿替美唑（160微克/千克）拮抗，因此这些变化被认为主要归因于美托咪定对α2-肾上腺素能受体的作用。在实验猪中，低剂量美托咪定与咪达唑仑联合使用可减少不良影响，同时提供比单独使用美托咪定更深的镇静作用。
