安替派唑对美托咪定-咪达唑仑诱导犬镇静的拮抗作用。

Antagonistic effects of antipamezole on medetomidine-midazolam induced sedation in dogs.

作者信息

Hayashi K, Nishimura R, Yamaki A, Kim H, Matsunaga S, Sasaki N, Takeuchi A

机构信息

Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

J Vet Med Sci. 1994 Oct;56(5):1009-11. doi: 10.1292/jvms.56.1009.

DOI:10.1292/jvms.56.1009

PMID:7865573

Abstract

Antagonistic effect of atipamezole (80 micrograms/kg) on medetomidine (20 micrograms/kg)-midazolam (0.3 mg/kg) induced sedation was evaluated in dogs. Atipamezole effectively reversed sedation and significantly shortened arousal time and total recovery time without apparent side effects. Atipamezole also effectively reversed changes in heart rate, respiratory rate and body temperature produced by medetomidine-midazolam. The possible use of atipamezole as a reversal agent might enhance the value and availability of medetomidine-midazolam for a chemical restraint agent in dogs.

摘要

在犬类中评估了阿替美唑（80微克/千克）对美托咪定（20微克/千克）-咪达唑仑（0.3毫克/千克）诱导的镇静作用的拮抗效果。阿替美唑有效逆转了镇静作用，并显著缩短了苏醒时间和总恢复时间，且无明显副作用。阿替美唑还有效逆转了美托咪定-咪达唑仑引起的心率、呼吸频率和体温变化。阿替美唑作为一种逆转剂的可能用途，可能会提高美托咪定-咪达唑仑作为犬类化学保定剂的价值和实用性。