阿替美唑对猪体内美托咪定镇静作用的拮抗作用。

Antagonism of medetomidine sedation by atipamezole in pigs.

作者信息

Nishimura R, Kim H, Matsunaga S, Sakaguchi M, Sasaki N, Tamura H, Takeuchi A

机构信息

Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

J Vet Med Sci. 1992 Dec;54(6):1237-40. doi: 10.1292/jvms.54.1237.

DOI:10.1292/jvms.54.1237

PMID:1362084

Abstract

The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 micrograms/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 micrograms/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 micrograms/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.

摘要

在猪身上评估了阿替美唑作为美托咪定拮抗剂的疗效。阿替美唑的剂量（肌肉注射）分别为80、160、320和480微克/千克体重，分别比先前的美托咪定剂量（80微克/千克，肌肉注射）高1、2、4和6倍。阿替美唑有效地逆转了美托咪定引起的镇静作用，在160和320微克/千克的剂量下观察到最佳效果。镇静恢复迅速且平稳，两种剂量下的多动或心动过速等不良反应均最小。