Takizawa T, Oda T, Arishima K, Yamamoto M, Somiya H, Eguchi Y, Shiota K
Department of Developmental Biotechnology, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
J Vet Med Sci. 1994 Jun;56(3):605-6. doi: 10.1292/jvms.56.605.
Caesarean newborn rats were given subcutaneously enalapril maleate (EM), an angiotensin-converting enzyme inhibitor, (1) immediately or (2) 180 min after delivery. The ductus arteriosus (DA) in these newborn pups was calibrated 30, 60 and 90 min after the EM-treatment. The results were as follows: (1) DA calibers of the pups given 10 or 50 mg/kg EM just at caesarean delivery remained significantly larger than those of the controls thereafter until 90 min. (2) The DA was completely closed 180 min after caesarean delivery. However, with 50 mg/kg EM given at this time, the DA was temporarily re-opened and then constricted. It is concluded that, in newborn rats, EM has the direct inhibitory action on the constriction of the DA, and that it also has the re-opening action on the once-constricted DA.
给剖腹产出生的新生大鼠皮下注射马来酸依那普利（EM，一种血管紧张素转换酶抑制剂），（1）在分娩后立即注射，或（2）在分娩后180分钟注射。在给予EM治疗后30、60和90分钟对这些新生幼崽的动脉导管（DA）进行测量。结果如下：（1）在剖腹产时给予10或50mg/kg EM的幼崽，其DA管径在此后直至90分钟时仍显著大于对照组。（2）剖腹产180分钟后DA完全关闭。然而，此时给予50mg/kg EM，DA会暂时重新开放然后收缩。得出的结论是，在新生大鼠中，EM对DA的收缩有直接抑制作用，并且对曾经收缩过的DA有重新开放作用。
