Davenport D S, Johnson D R, Holmes G P, Jewett D A, Ross S C, Hilliard J K
Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo.
Clin Infect Dis. 1994 Jul;19(1):33-41. doi: 10.1093/clinids/19.1.33.
Three men who had worked at the same animal research facility and had had contact with macaque monkeys were infected with B virus (Herpesvirus simiae). Their clinical presentations varied from self-limited aseptic meningitis syndrome to fulminant encephalomyelitis and death. Patient 1 was treated only after a respiratory arrest and other signs of advanced brain stem dysfunction had occurred. He died 8 days after hospital admission, despite treatment with acyclovir. Patient 2 presented with subtle signs and symptoms of brain stem encephalitis. He received antiviral therapy with intravenous ganciclovir. Patient 3 had a headache without meningismus and was also treated with acyclovir. Both patients 2 and 3 survived and did not have objective sequelae. Viral culturing, ELISA and western blot antibody testing, and magnetic resonance imaging all proved useful in the diagnosis of these patients' conditions.
三名曾在同一动物研究机构工作并接触过猕猴的男子感染了B病毒（猴疱疹病毒）。他们的临床表现从自限性无菌性脑膜炎综合征到暴发性脑脊髓炎并死亡不等。患者1在出现呼吸骤停和其他晚期脑干功能障碍迹象后才接受治疗。尽管接受了阿昔洛韦治疗，但他在入院8天后死亡。患者2表现出脑干脑炎的细微体征和症状。他接受了静脉注射更昔洛韦的抗病毒治疗。患者3有头痛但无颈项强直，也接受了阿昔洛韦治疗。患者2和患者3均存活且无客观后遗症。病毒培养、ELISA和western blot抗体检测以及磁共振成像在诊断这些患者的病情方面均被证明是有用的。
