Tyszkiewicz Z, Nowosławski A, Biel J
Pol Med Sci Hist Bull (1973). 1976 Oct-Dec;15-16(4):339-50.
The effect of Imuran on experimental Masugi glomerulonephritis was checked in rabbits. The animals were grouped in biologically most similar pairs: one of the mates was treated with Imuran (4 or 8 mg/kg daily) the other served as control. Clinical and laboratory investigations were supplemented by histological and immunofluorescent studies of renal specimens taken on the 1st, 3rd, 7th, 10th, 21st, and 35th day of observation. The course of glomerulonephritis appeared much milder in Imuran-treated animals with a morphological counterpart in the form of reduced glomerular exudation and cellular proliferation. Only a slight and inconstant decrease of deposition of rabbit gamma-globulin and fibrin was observed in treatment animals in later stages of the experiment. Without denying a slight immunosuppressive effect, the authors admit that, in doses below 8 mg/kg daily, Imuran exerts a rather antiininflammatory effect on experimental glomerulonephritis.
在兔子身上检查了硫唑嘌呤对实验性马休基肾小球肾炎的影响。将动物按生物学上最相似的配对分组：一对中的一只用硫唑嘌呤治疗（每日4或8毫克/千克），另一只作为对照。在观察的第1、3、7、10、21和35天采集肾脏标本进行组织学和免疫荧光研究，以补充临床和实验室检查。在接受硫唑嘌呤治疗的动物中，肾小球肾炎的病程似乎要轻得多，其形态学对应表现为肾小球渗出和细胞增殖减少。在实验后期，仅在治疗动物中观察到兔γ球蛋白和纤维蛋白沉积有轻微且不稳定的减少。作者在不否认有轻微免疫抑制作用的情况下承认，在每日剂量低于8毫克/千克时，硫唑嘌呤对实验性肾小球肾炎有相当的抗炎作用。
