Abdel-Fattah W I, Osiris W G, Mohamed S S, Khalil M R
Ceramic Department, National Research Center, Egypt.
Biomaterials. 1994 Jun;15(8):609-14. doi: 10.1016/0142-9612(94)90211-9.
A newly developed bone equivalent hydroxyapatite was derived from veterinary bone (VHAP). Sections of 1 cm of six rabbit mandibles were equally replaced by this VHAP graft. Radiological studies by X-ray were performed pre-operatively, immediately, and 1, 2 and 3 months post-operatively. The graft host-bone interface was examined periodically by scanning electron microscopy (SEM). Accompanying structural changes of the graft 3 months post-operatively were compared with the pre-operative findings by infra-red (IR) spectroscopic analysis. Complete union of the biomaterial to the host bone after 3 months was evidenced radiologically. SEM proved complete graft integration. This was accompanied by a decrease in optical density of the IR analysis of post-operative VHAP, indicating some leaching of the ions. Clinically, the graft was completely incorporated in the mandible without any complications. We discuss the use of VHAP in humans to reconstruct post-surgical mandibular defects.
一种新开发的骨替代物羟基磷灰石源自兽骨（VHAP）。用这种VHAP移植物等量替换了六只兔子下颌骨1厘米长的部分。术前、术后即刻以及术后1、2和3个月进行了X射线影像学研究。通过扫描电子显微镜（SEM）定期检查移植物与宿主骨的界面。术后3个月移植物伴随的结构变化通过红外（IR）光谱分析与术前结果进行比较。影像学证据显示3个月后生物材料与宿主骨完全结合。SEM证明移植物完全整合。这伴随着术后VHAP红外分析光密度的降低，表明有一些离子浸出。临床上，移植物完全融入下颌骨，无任何并发症。我们讨论了VHAP在人类中用于重建术后下颌骨缺损的应用。
