Gallese V, Murata A, Kaseda M, Niki N, Sakata H
Department of Physiology, Nihon University School of Medicine, Tokyo, Japan.
Neuroreport. 1994 Jul 21;5(12):1525-9. doi: 10.1097/00001756-199407000-00029.
In order to assess the functional role of the parietal hand movement region, the anterior part of the lateral bank of the intraparietal sulcus (IPS), area AIP, in the visual guidance of hand grasping, we reversibly inactivated several parts of this area with microinjections of Muscimol in a monkey trained to grasp objects of different shapes, sizes and orientations. During the local inactivation, some of the skilled patterns of finger movements were disrupted in the contralateral hand, due to the lack of preshaping to adjust the finger posture to the object; however, no major deficits in visual reaching were observed. The results suggest that area AIP plays a crucial role in the visual guidance of goal-directed hand movements.
为了评估顶叶手部运动区域，即顶内沟（IPS）外侧壁前部AIP区，在手部抓握视觉引导中的功能作用，我们在一只经过训练抓握不同形状、大小和方向物体的猴子身上，通过微量注射蝇蕈醇可逆性地失活该区域的几个部分。在局部失活期间，对侧手的一些熟练手指运动模式受到干扰，原因是缺乏预塑形来根据物体调整手指姿势；然而，未观察到视觉够物方面的重大缺陷。结果表明，AIP区在目标导向性手部运动的视觉引导中起关键作用。
