Deppert W
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Germany.
Semin Cancer Biol. 1994 Jun;5(3):187-202.
The tumor suppressor p53 is a key element in preserving the stability of the genetic information of vertebrates. In response to DNA damage, PSS induces a growth arrest thus allowing time for DNA repair to occur. However, p53 seems to exert additional functions in cellular proliferation, amongst them a so far unidentified role in the progression of cells through the cell cycle and in differentiation processes. Modulation of p53 activities, by regulating p53 interactions with different target genes and cellular protein partners through the cellular environment might explain the diversity of p53 functions in cellular growth control.
肿瘤抑制因子p53是维持脊椎动物遗传信息稳定性的关键要素。响应DNA损伤时，p53会诱导细胞生长停滞，从而为DNA修复留出时间。然而，p53似乎在细胞增殖中发挥着额外功能，其中包括在细胞通过细胞周期进程和分化过程中迄今尚未明确的作用。通过细胞环境调节p53与不同靶基因及细胞蛋白伙伴的相互作用来调控p53活性，可能解释了p53在细胞生长控制中功能的多样性。
