Lewis S M
Division of Biology, California Institute of Technology, Pasadena 91125.
Semin Immunol. 1994 Jun;6(3):131-41. doi: 10.1006/smim.1994.1019.
The fine-structures of V(D)J joining products present a cache of information about the recombination process. Testable hypotheses with predictive value are beginning to provide a surprisingly detailed picture of the joining operation. Here, one feature of V(D)J junctions, the appearance of short palindromic inserts, is discussed, and experimental evidence in support of a joining model involving a hairpin-terminated DNA intermediate will be summarized.
V(D)J连接产物的精细结构蕴含着有关重组过程的大量信息。具有预测价值的可测试假设开始为连接操作提供一幅惊人详细的图景。在此，将讨论V(D)J接头的一个特征，即短回文插入序列的出现，并总结支持涉及发夹末端DNA中间体的连接模型的实验证据。
