Lieber M R, Chang C P, Gallo M, Gauss G, Gerstein R, Islas A
Department of Pathology, Stanford University School of Medicine, CA 94305-5324.
Semin Immunol. 1994 Jun;6(3):143-53. doi: 10.1006/smim.1994.1020.
Site-specific recombination reactions in higher eukaryotes are uncommon, perhaps because of the potential genomic instability that they may create. We focus this review on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.
高等真核生物中的位点特异性重组反应并不常见，这可能是因为它们可能会导致潜在的基因组不稳定性。我们将这篇综述聚焦于V(D)J重组反应中的位点特异性、反应保真度和免疫多样性问题。
