Hromadová M, Parrák V, Huttová M, Danová K, Urvölgyová M
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
Endocr Regul. 1994 Mar;28(1):47-52.
To obtain a rather complex picture on fat metabolism in newborns, fundamental characteristics of this metabolism as well as the carnitine level in their blood was correlated with corresponding values from cord blood, maternal blood and milk. The concentrations of cholesterol (CHOL), triglycerides (TGL) and apolipoprotein B (Apo-B) in 4 days old infants were higher than in cord blood (P < 0.01 and P < 0.001, resp.), but were only 50% of those in blood of the respective mothers. No differences in HDL-CHOL were observed, whereas the level of apolipoprotein A (Apo-A) in cord blood exceeded that in newborn blood (P < 0.05). The level of carnitine in milk was about twice as high as in maternal blood (P < 0.001) which was the consequence of the high acylcarnitine content in milk. Our results represent a basis for comparison of normal and pathologically altered metabolic situation, e.g. in hypotrophic newborns and potentially in newborns in need of parenteral nutrition.
为了全面了解新生儿脂肪代谢的复杂情况，将这种代谢的基本特征以及新生儿血液中的肉碱水平与脐带血、母体血液和乳汁中的相应值进行了关联。4日龄婴儿血液中胆固醇（CHOL）、甘油三酯（TGL）和载脂蛋白B（Apo-B）的浓度高于脐带血（分别为P < 0.01和P < 0.001），但仅为各自母亲血液中浓度的50%。高密度脂蛋白胆固醇（HDL-CHOL）没有差异，而脐带血中载脂蛋白A（Apo-A）的水平超过新生儿血液中的水平（P < 0.05）。乳汁中的肉碱水平约为母体血液中的两倍（P < 0.001），这是由于乳汁中高含量的酰基肉碱所致。我们的研究结果为比较正常和病理改变的代谢状况奠定了基础，例如在低体重新生儿以及可能需要肠外营养的新生儿中。
