Aminoglycoside pharmacokinetics: volume of distribution in specific adult patient subgroups.

OBJECTIVE

To review the published clinical studies reporting volume of distribution for aminoglycosides in patient population subgroups. Controversies in methods used are discussed.

DATA SOURCES

National Library of Medicine Medlars, searched using MEDLINE.

STUDY SELECTION

Published articles primarily relating to pharmacokinetic properties of aminoglycosides in specific adult patient subgroups published within the past 20 years were included. Pediatric studies were excluded.

DATA EXTRACTION

The methodology, assay technique, and results from clinical studies reporting aminoglycoside volume of distribution were evaluated.

DATA SYNTHESIS

Clinical studies reporting aminoglycoside volume of distribution subgroups, including the methods by which their results were derived, are tabulated.

CONCLUSIONS

The expected aminoglycoside volume of distribution can vary, depending on a patient's clinical presentation. Data presented will allow a more refined initial estimation of volumes of distribution, which may facilitate the achievement of desired aminoglycoside serum concentrations.