Goodall S, Reggia J A, Cho S
Dept. of Computer Science, Univ. of Maryland College Park 20742.
Proc Annu Symp Comput Appl Med Care. 1994:860-4.
Determining how feature maps in the cerebral cortex adapt to sudden, focal damage is important for gaining a deeper understanding of neurological illnesses such as stroke. In this paper we describe a neural model of the region of primary sensory cortex related to upper extremity proprioception, and show how the feature map there reorganizes following a simulated lesion. A perilesion zone with decreased activity appears and then gradually expands with time. These results differ from those seen with previous models of cortical lesions, and offer an alternative mechanism to the "ischemic penumbra" seen in certain types of stroke.
确定大脑皮层中的特征图如何适应突发性局灶性损伤，对于更深入地理解中风等神经系统疾病至关重要。在本文中，我们描述了与上肢本体感觉相关的初级感觉皮层区域的神经模型，并展示了该区域的特征图在模拟损伤后是如何重新组织的。一个活动减少的损伤周围区域出现，然后随着时间逐渐扩大。这些结果与先前的皮质损伤模型不同，并为某些类型中风中出现的“缺血半暗带”提供了一种替代机制。
