Syversen J H, Mollestad E, Semb L S
Scand J Urol Nephrol. 1976;10(3):201-3. doi: 10.1080/21681805.1976.11882074.
To find out whether Cetiprin reduces the vesical spasms seen after cystotomias, a double-blind investigation including 22 men was carried out. Eleven of the men were given 25 mg Cetiprin i.m. twice a day for 2 days after transvesical prostatectomy, then 200 mg orally 3 times a day the following 12 days. The rest of the men, 11 patients, received placebo. In the Cetiprin group 9 patients had no vesical spasm postoperatively, whereas 1 had moderate and 1 had severe spasms. Only 4 patients were without spasms in the control group, whereas 5 had moderate and 2 severe spasms. The postoperative reduction of the bladder volume were counteracted by Cetiprin. No significant influence on liver- or kidney function was seen with the dosages mentioned.
为了确定西替普林是否能减轻膀胱切开术后出现的膀胱痉挛，开展了一项包括22名男性的双盲研究。其中11名男性在经膀胱前列腺切除术后，每天两次肌肉注射25毫克西替普林，共2天，随后的12天里每天口服200毫克，一天3次。其余11名患者接受安慰剂治疗。在西替普林组中，9名患者术后无膀胱痉挛，1名有中度痉挛，1名有重度痉挛。对照组中只有4名患者无痉挛，5名有中度痉挛，2名有重度痉挛。西替普林抵消了术后膀胱容量的减少。上述剂量对肝肾功能未见显著影响。
