Qian B C, Chen J, Xu H J
Inst. of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Apr;14(4):227-9, 198.
Pharmacological action of 101-B hair regeneration extract (101-B) on skin and hair was studied in experimental animals. The results were as follows: (1) In normal rats, guinea pigs and rabbits the weight of regrown hairs in shaved area in 101-B group was significantly heavier than that in alcohol group. (2) Hair loss induced by oral administration of thallium carbonate 2 mg/kg every other day for 10 times was obviously prevented by topical treatment of 101-B. (3) Itching threshold to histamine or papain in guinea pig was elevated after using of 101-B topically. (4) The diameter of skin ulcer caused by intradermal injection of adriamycin in rats was diminished in 101-B group. (5) Observation in skin microcirculation in mice indicated that both normal skin microcirculation and disturbed microcirculation induced by endotoxin were improved with administration of 101-B. Above experimental results provided preliminary evidence for clinical use of 101-B.
在实验动物中研究了101 - B毛发再生提取物（101 - B）对皮肤和毛发的药理作用。结果如下：（1）在正常大鼠、豚鼠和兔子中，101 - B组剃毛区域再生毛发的重量明显重于酒精组。（2）每隔一天口服2mg/kg碳酸铊，连续给药10次诱导的脱发，经101 - B局部治疗后明显得到预防。（3）局部使用101 - B后，豚鼠对组胺或木瓜蛋白酶的瘙痒阈值升高。（4）101 - B组大鼠皮内注射阿霉素引起的皮肤溃疡直径减小。（5）对小鼠皮肤微循环的观察表明，101 - B给药可改善正常皮肤微循环以及内毒素诱导的紊乱微循环。上述实验结果为101 - B的临床应用提供了初步证据。
