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荟萃分析及其问题。

Meta-analysis and its problems.

作者信息

Eysenck H J

机构信息

Institute of Psychiatry, London.

出版信息

BMJ. 1994 Sep 24;309(6957):789-92. doi: 10.1136/bmj.309.6957.789.

Abstract

Including all relevant material--good, bad, and indifferent--in meta-analysis admits the subjective judgments that meta-analysis was designed to avoid. Several problems arise in meta-analysis: regressions are often non-linear; effects are often multivariate rather than univariate; coverage can be restricted; bad studies may be included; the data summarised may not be homogeneous; grouping different causal factors may lead to meaningless estimates of effects; and the theory-directed approach may obscure discrepancies. Meta-analysis may not be the one best method for studying the diversity of fields for which it has been used.

摘要

在荟萃分析中纳入所有相关材料——好的、坏的和一般的——会承认荟萃分析旨在避免的主观判断。荟萃分析中会出现几个问题:回归通常是非线性的;效应通常是多变量而非单变量的;覆盖范围可能有限;可能会纳入质量差的研究;汇总的数据可能不是同质的;将不同的因果因素分组可能会导致对效应的无意义估计;而且理论导向的方法可能会掩盖差异。荟萃分析可能不是研究其应用领域多样性的最佳方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca5/2541015/32e48177d3c7/bmj00458-0044-a.jpg

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