[不同剂量的γ-氨基丁酸（GABA）激动剂和拮抗剂中枢给药期间大鼠脑电活动的变化]

[Changes in the electrical activity of the rat brain during the central administration of different doses of GABA agonists and antagonists].

作者信息

Iarkov A V, Kovalev G I, Gal'chenko A A

出版信息

Eksp Klin Farmakol. 1994 Jul-Aug;57(4):6-11.

Abstract

The changes in the frequency content of electrograms of the optic cortical area and deep structures of the brain (putamen, dorsal hippocampus, medial part of the hypothalamus) were studied during intraventricular introduction of various doses of GABA-receptor agonists (GABA, muscimol, baclofen) and antagonist (bicuculline). The latter was found to affect the overall electrical activity slightly regardless of the dose. When muscimol and baclofen were injected, the greatest EG effect was observed at 1.10(-9) mole. A dose-dependent reversion of EG effects was revealed for GABA and muscimol; at the alpha-range 1.10(-6) mole, of GABA was found to weaken rhythmic activity, while 1.10(-8) mole of muscimol increased and 1.10(-9) mole decreased the power of alpha-rhythm. The correlation analysis of EG changes suggests that there is one interdependent mechanism or more for formation of EG of the range studied which operate by the starting mechanism.

摘要

在脑室内注入不同剂量的GABA受体激动剂（GABA、蝇蕈醇、巴氯芬）和拮抗剂（荷包牡丹碱）时，研究了视皮层区域和脑深部结构（壳核、背侧海马、下丘脑内侧部分）电图频率成分的变化。结果发现，无论剂量如何，后者对整体电活动的影响都很小。注射蝇蕈醇和巴氯芬时，在1.10（-9）摩尔时观察到最大的脑电图效应。GABA和蝇蕈醇的脑电图效应呈剂量依赖性逆转；在1.10（-6）摩尔的α范围内，GABA会减弱节律性活动，而1.10（-8）摩尔的蝇蕈醇会增加α节律的功率，1.10（-9）摩尔则会降低其功率。脑电图变化的相关性分析表明，在所研究的频率范围内，脑电图的形成存在一种或多种相互依存的机制，这些机制通过启动机制起作用。