Yarkov A V, Vorob'ev V V, Kovalev G I
Laboratory of Medical Biophysics, Russian Academy of Sciences, Pushchino.
Neurosci Behav Physiol. 1993 Jan-Feb;23(1):76-82. doi: 10.1007/BF01182642.
The frequency composition of the electrograms (EG) of the visual area of the cortex and deep brain structures (putamen, dorsal hippocampus, medial portion of the mid-hypothalamus) were investigated in chronic experiments in 36 awake rats under the conditions of the separate and combined introduction of GABA, its agonists (muscimol, baclofen), and an antagonist (bicuculline) into the lateral ventricle of the brain. The principal effects were manifested primarily in the form of a decrease in the power of the oscillations in the 7-16 Hz region of the range (1-25 Hz) of EG frequencies analyzed. Even though these changes were unidirectional following the administration of the agonists, they nevertheless differed with respect to the degree of expressivity in the different structures. Bicuculline, injected against the background of the action of muscimol and baclofen, attenuated the effects induced by them. The possible mechanisms of the phenomena discovered are discussed.
在36只清醒大鼠的慢性实验中，研究了在分别和联合向脑侧脑室注射γ-氨基丁酸（GABA）、其激动剂（蝇蕈醇、巴氯芬）和拮抗剂（荷包牡丹碱）的条件下，大脑皮层视觉区以及深部脑结构（壳核、背侧海马、下丘脑中部内侧部分）的电图（EG）的频率组成。主要效应主要表现为所分析的EG频率范围（1-25Hz）中7-16Hz区域振荡功率的降低。尽管在给予激动剂后这些变化是单向的，但它们在不同结构中的表达程度仍有所不同。在蝇蕈醇和巴氯芬作用的背景下注射荷包牡丹碱，减弱了它们所诱导的效应。文中讨论了所发现现象的可能机制。
