Nojima K, Isogami C, Itoh Y, Takahashi Y, Kobashi M
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Biol Pharm Bull. 1994 Jun;17(6):819-22. doi: 10.1248/bpb.17.819.
The reaction of styrene with sodium hypochlorite in the presence of ammonium ion in 0.3 M phosphate buffer (pH 6.0) at room temperature afforded N-chloro-1-phenyl-2-chloroethylamine and N,N-dichloro-1-phenyl-2-chloroethylamine. 1-Phenyl-2-chloroethylamine hydrochloride, obtained as the reduction product of the two N-chloroamines, was shown to be mutagenic in the Salmonella typhimurium test.
在室温下，苯乙烯与次氯酸钠在0.3M磷酸缓冲液（pH 6.0）中铵离子存在的条件下反应，生成N-氯-1-苯基-2-氯乙胺和N,N-二氯-1-苯基-2-氯乙胺。作为两种N-氯胺还原产物得到的1-苯基-2-氯乙胺盐酸盐，在鼠伤寒沙门氏菌试验中显示具有致突变性。
