Horwich A, Stenning S
Urological Oncology Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
World J Urol. 1994;12(3):148-50. doi: 10.1007/BF00192276.
A retrospective survival analysis was performed on 287 patients treated with chemotherapy following orchidectomy for stage II testicular non-seminoma between 1982 and 1986 at a number of centres in the United Kingdom and 1 centre in Norway. A total of 80 patients had lymphadenectomy for a residual mass after chemotherapy. In 17 of these cases the histology was undifferentiated malignancy, in 44 it was differentiated teratoma, in 18 there was necrosis only and in 1 case histology was unknown. The overall survival in 47 patients with initial stage IIA disease (nodes measuring < 2 cm in transverse diameter) was 98% [95% confidence interval (CI), 96%-100%] at 3 years. In 175 patients with stage IIB disease (nodal diameter, 2-5 cm) the 3-year survival was 96% (95% CI, 93%-99%) and in 65 patients with stage IIC disease (nodal diameter, > 5 cm) it was 84% (95% CI, 75%-93%). In stage IIA and stage IIB disease this approach leads to survival equivalent to that obtained with the approach of initial retroperitoneal lymph-node dissection.
对1982年至1986年间在英国多个中心和挪威1个中心接受睾丸切除术后化疗的287例II期睾丸非精原细胞瘤患者进行了回顾性生存分析。共有80例患者在化疗后因残留肿块接受了淋巴结清扫术。其中17例组织学为未分化恶性肿瘤，44例为分化型畸胎瘤，18例仅有坏死，1例组织学情况不明。47例初始为IIA期疾病（横径<2 cm的淋巴结）患者的3年总生存率为98%[95%置信区间（CI），96%-100%]。175例IIB期疾病（淋巴结直径2-5 cm）患者的3年生存率为96%（95% CI，93%-99%），65例IIC期疾病（淋巴结直径>5 cm）患者的3年生存率为84%（95% CI，75%-93%）。在IIA期和IIB期疾病中，这种方法导致的生存率与初始腹膜后淋巴结清扫术的方法相当。
