Lieverse R J, Jansen J B, Masclee A A, Lamers C B
Department of Gastroenterology and Hepatology, University Hospitals of Leiden, The Netherlands.
Int J Obes Relat Metab Disord. 1994 Aug;18(8):579-83.
The aim of this work was to determine whether infusion of bombesin inhibits intake of a carbohydrate-rich meal in lean and obese women. A double blind study was carried out using bombesin or saline infusion. The subjects were nine lean and nine obese women of the same age. Food intake and hunger feelings were measured. During infusion of bombesin, the amount of food eaten by the lean individuals (294 +/- 55 g) was significantly less than during infusion of saline (467 +/- 69 g, P < 0.01). However, bombesin induced no significant feeding suppression in the obese women when compared to saline (431 +/- 60 vs 499 +/- 99 g). Subjective hunger feelings were significantly affected by bombesin infusion in the lean subjects only. It was concluded that bombesin infusion inhibits food intake and increases satiety in lean women, whereas obese women are less sensitive to these bombesin-induced satiety effects.
这项研究的目的是确定输注蛙皮素是否会抑制瘦女性和肥胖女性对富含碳水化合物食物的摄入量。采用蛙皮素或生理盐水输注进行了一项双盲研究。受试者为9名年龄相同的瘦女性和9名肥胖女性。测量了食物摄入量和饥饿感。在输注蛙皮素期间，瘦个体摄入的食物量（294±55克）明显少于输注生理盐水期间（467±69克，P<0.01）。然而，与生理盐水相比，蛙皮素对肥胖女性的进食抑制作用不显著（431±60克对499±99克）。主观饥饿感仅在瘦受试者中受到蛙皮素输注的显著影响。得出的结论是，输注蛙皮素会抑制瘦女性的食物摄入量并增加饱腹感，而肥胖女性对这些蛙皮素诱导的饱腹感效应不太敏感。
