Kazumi T, Ricquier D, Maeda T, Masuda T, Hozumi T, Ishida Y, Yoshida M
Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan.
Endocr J. 1994 Jun;41(3):315-8. doi: 10.1507/endocrj.41.315.
We report a case of benign symmetric lipomatosis with hypothyroidism. Functional abnormalities and distribution of lipomas in benign symmetric lipomatosis suggest that the lipomas in this disorder may represent brown adipose tissue. In conditions where mRNAs of uncoupling protein, which is believed to be unique for brown adipose tissue mitochondria, were detected in one microgram of poly (A+) rat brown fat RNA, no signal at all was found in the lipomatous tissue, suggesting that the masses of benign symmetric lipomatosis are not functional brown adipose tissue.
我们报告一例合并甲状腺功能减退的良性对称性脂肪瘤病。良性对称性脂肪瘤病中脂肪瘤的功能异常及分布提示，该疾病中的脂肪瘤可能代表褐色脂肪组织。在每微克聚腺苷酸 [poly(A+)] 大鼠褐色脂肪RNA中可检测到解偶联蛋白的信使核糖核酸（mRNA），而褐色脂肪组织线粒体被认为该蛋白是其独有的，在脂肪瘤组织中却未发现任何信号，这表明良性对称性脂肪瘤病的肿块并非功能性褐色脂肪组织。
