Frisoni G B, Calabresi L, Geroldi C, Bianchetti A, D'Acquarica A L, Govoni S, Sirtori C R, Trabucchi M, Franceschini G
Alzheimer's Disease Unit, Istituto S. Cuore-FBF, Brescia, Italy.
Dementia. 1994 Sep-Oct;5(5):240-2. doi: 10.1159/000106730.
The frequency of the epsilon 4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer's disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown. We found that the frequency of the apoE epsilon 4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly controls. The association of apoE epsilon 4 allele is not unique to Alzheimer's disease, and its importance as a risk factor for the disease should be reconsidered.
载脂蛋白E（apoE）的ε4等位基因在家族性和散发性晚发性阿尔茨海默病中的频率增加，但其在白种人群非阿尔茨海默病性痴呆中的患病率尚不清楚。我们发现，93例阿尔茨海默病患者中apoE ε4等位基因的频率为0.45，23例血管性痴呆患者中为0.46，13例额颞叶型痴呆患者中为0.31，51例老年对照者中为0.18。apoE ε4等位基因的关联并非阿尔茨海默病所特有，应重新考虑其作为该病危险因素的重要性。
