年龄对内嗅皮质和海马萎缩率的影响。
Age effects on atrophy rates of entorhinal cortex and hippocampus.
作者信息
Du An-Tao, Schuff Norbert, Chao Linda L, Kornak John, Jagust William J, Kramer Joel H, Reed Bruce R, Miller Bruce L, Norman David, Chui Helena C, Weiner Michael W
机构信息
Magnetic Resonance Unit (114M), Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA.
出版信息
Neurobiol Aging. 2006 May;27(5):733-40. doi: 10.1016/j.neurobiolaging.2005.03.021. Epub 2005 Jun 14.
The effects of age, subcortical vascular disease, apolipoprotein E (APOE) epsilon4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, and white matter hyperintensities (WMH) and the presence of lacunes were assessed on MR images. Age was significantly associated with increased atrophy rates of 0.04+/-0.02% per year for ERC and 0.05+/-0.02% per year for hippocampus. Atrophy rates of hippocampus, but not that of ERC increased with presence of lacunes, in addition to age. WMH, APOE epsilon4 and hypertension had no significant effect on atrophy rates. In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials.
在一项针对42名年龄在58至87岁之间认知正常（CN）的老年受试者的纵向MRI研究中，探讨了年龄、皮质下血管疾病、载脂蛋白E（APOE）ε4等位基因和高血压对内嗅皮质（ERC）和海马萎缩率的影响。在MR图像上评估了ERC、海马的体积、白质高信号（WMH）以及腔隙的存在情况。年龄与ERC每年0.04±0.02%以及海马每年0.05±0.02%的萎缩率增加显著相关。除年龄外，海马萎缩率随腔隙的存在而增加，但ERC的萎缩率未增加。WMH、APOE ε4和高血压对萎缩率无显著影响。总之，在对CN受试者和AD患者的影像学研究中，应考虑年龄和腔隙的存在，以预测AD进展并评估对治疗试验的反应。
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