芬兰老年男性中的载脂蛋白E多态性、阿尔茨海默病和血管性痴呆
Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men.
作者信息
Stengård J H, Pekkanen J, Sulkava R, Ehnholm C, Erkinjuntti T, Nissinen A
机构信息
National Public Health Institute, Helsinki, Finland.
出版信息
Acta Neurol Scand. 1995 Oct;92(4):297-8. doi: 10.1111/j.1600-0404.1995.tb00132.x.
An association between late-onset Alzheimer's disease, vascular dementia and the common polymorphic alleles of the gene coding for apolipoprotein E, epsilon 2, epsilon 3, and epsilon 4, was assessed in a population sample of 393 elderly Finnish men aged 70 to 89 years. Of them, 7% suffered Alzheimer's disease and 3% had vascular dementia. Among those who suffered Alzheimer's disease, there was a statistically significant excess of the epsilon 4 allele. No such an association was observed between the apolipoprotein E alleles and vascular dementia. We conclude that the apolipoprotein E polymorphism confers information about a risk of Alzheimer's disease in this population sample of elderly Finnish men.
在一个由393名年龄在70至89岁之间的芬兰老年男性组成的人群样本中，研究了迟发性阿尔茨海默病、血管性痴呆与编码载脂蛋白E的基因（ε2、ε3和ε4）常见多态性等位基因之间的关联。其中，7%的人患有阿尔茨海默病，3%的人患有血管性痴呆。在患有阿尔茨海默病的人群中，ε4等位基因在统计学上显著过量。在载脂蛋白E等位基因与血管性痴呆之间未观察到此类关联。我们得出结论，在这个芬兰老年男性人群样本中，载脂蛋白E多态性提供了有关阿尔茨海默病风险的信息。
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