Horiike N, Onji M, Kumamoto I, Masumoto T
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
J Gastroenterol. 1994 Aug;29(4):455-9. doi: 10.1007/BF02361243.
Intercellular adhesion molecule-1 (ICAM-1) is expressed on the hepatocyte membrane in patients with chronic hepatitis B and C. We assayed levels of the soluble form of this molecule (sICAM-1) in serum by an enzyme-linked immunosorbent assay method; we then analyzed the results in relation to hepatitis activity. Fifty-one patients with chronic hepatitis (22 with type B and 29 with type C) and 10 normal controls were examined. The serum levels of sICAM-1 in hepatitis B and C were significantly higher (P < 0.01) than in normal controls. The serum level of sICAM-1 was correlated with serum glutamic-pyruvic transaminase level (P < 0.01), and the level of sICAM-1 in patients in whom exacerbation was seen was significantly higher (P < 0.05) than that in patients in a remission. There was no relationship between the serum level of sICAM-1 and the degree of ICAM-1 expression on the hepatocyte membrane. These results suggest that the serum level of sICAM-1 reflects the degree of activity of chronic hepatitis B and C.
细胞间黏附分子-1（ICAM-1）在慢性乙型和丙型肝炎患者的肝细胞膜上表达。我们采用酶联免疫吸附测定法检测血清中该分子可溶性形式（sICAM-1）的水平；然后分析结果与肝炎活动度的关系。对51例慢性肝炎患者（22例乙型肝炎患者和29例丙型肝炎患者）及10名正常对照者进行了检查。乙型和丙型肝炎患者血清中sICAM-1水平显著高于正常对照者（P<0.01）。sICAM-1血清水平与血清谷丙转氨酶水平相关（P<0.01），病情加重患者的sICAM-1水平显著高于病情缓解患者（P<0.05）。sICAM-1血清水平与肝细胞膜上ICAM-1表达程度之间无相关性。这些结果表明，sICAM-1血清水平反映了慢性乙型和丙型肝炎的活动程度。
