Konopliannikova O A, Konopliannikov A G, Vacek A
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):514-9.
The fraction of the survived intestinal crypts associated with patches of Peyer is higher to those non-patch-associated crypts of mice for three inbred strains. The difference in the survival between associated and non-patch-associated crypts increases with dose of gamma-irradiation. This difference for old mice is less than for young mice. Pre-irradiation (5 Gy) of mice one week before the conditioned gamma-irradiation cannot modify the difference in the survival between associated and non-patch-associated crypts. Radioprotection of mice by hypoxic gas mixture (10% O2) cannot modify this difference. Pre-treatment of mice by dextran-sulfate alone or in combination with hypoxic gas mixture decreased the survival of intestinal crypts associated with patches of Peyer to the level of non-path-associated crypts. The difference in the survival between two subpopulation of intestinal stem cells is less after neutron irradiation than after gamma-irradiation.
对于三种近交系小鼠，与派伊尔结斑块相关的存活肠隐窝比例高于那些与斑块不相关的隐窝。相关隐窝和非斑块相关隐窝之间的存活差异随γ射线照射剂量增加。老年小鼠的这种差异小于幼年小鼠。在条件性γ射线照射前一周对小鼠进行预照射（5 Gy）不能改变相关隐窝和非斑块相关隐窝之间的存活差异。低氧气体混合物（10% O2）对小鼠的辐射防护不能改变这种差异。单独用硫酸葡聚糖或与低氧气体混合物联合对小鼠进行预处理，可使与派伊尔结斑块相关的肠隐窝存活率降至与非斑块相关隐窝的水平。中子照射后，肠干细胞两个亚群之间的存活差异小于γ射线照射后。
